1Pharmaco-Biological Department, School of Pharmacy, University of Messina, Vill. Annunziata, 98168 Messina, Italy
The effect of cannabinoid drugs (i.p.) on cold/restraint stress-induced gastric ulcers was studied in rats. The cannabinoid receptor agonist (WIN 55,212-2, 0.1-1 mg/kg), but not the less active isomer WIN 55,212-3 (1 mg/kg), reduced gastric ulceration. The protective effect of WIN 55,212-2 (1 mg/kg) was counteracted by the cannabinoid CB1 receptor antagonist SR141716A, but not by the cannabinoid CB2 receptor antagonist SR144528. These results indicate that the antiulcer effect of the cannabinoid receptor agonist WIN 55,212-2 is mediated by cannabinoid CB1 receptors.
Journal
Naunyn-Schmiedeberg's Archives of Pharmacology
Publisher
Springer Berlin / Heidelberg
ISSN
0028-1298 (Print) 1432-1912 (Online)
Issue
Volume 363, Number 2 / January, 2001
Category
Short Communication
DOI
10.1007/s002100000360
Pages
241-244
Subject Collection
Biomedical and Life Sciences
SpringerLink Date
Thursday, February 19, 2004
Authors
2Biomorphology Department, School of Medicine, University of Messina, Messina, Italy
3Department of Experimental Pharmacology, University of Naples "Federico II", via D. Montesano 49, 80131 Naples, Italy
4Department of Pharmaceutical Sciences, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
Abstract
Keywords
Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats
Maria Paola Germanò, Valeria D'Angelo, Maria Rita Mondello, Simona Pergolizzi, Francesco Capasso, Raffaele Capasso, Angelo A. Izzo, Nicola Mascolo, Rita De Pasquale
Cannabinoid receptors, Antiulcer activity, Stomach, Gastroprotection