Immunology Biol 390

Syllabus-We will use i clickers in this class so please purchase one for the start of class. There is no text for this class. You will be reading peer reviewed articles with a little help from Wiki.

Class structure and introduction to PubMed, Physics of Life

The immune system as as a natural emergent phenomenon consistent with the laws of far from equilibrium thermodynamics spaciotemporal structures

Free Radicals What are they?

Cell to Cell Communication: receptors and ligands, Limit Cycles, Oscillations

The Innate Immune System The Complement System, A video of complement Self, non-self, and danger: a complementary view, The ancestry and cumulative evolution of immune reactions , Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation.

Oxidative Stress and the Regulation of Complement Activation in Human Glaucoma, The immune response in glaucoma: A perspective on the roles of oxidative stress.

Innate Immune System Receptors: Toll-Like Receptors (TLRs) flagellin TLR5, Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia. oxidative stress (lung) TLR4, oxidative stress (retinal) TLR4, Dietary sugars inhibit biologic functions of the pattern recognition molecule, mannose-binding lectin

Cell Death Necrosis necrotic cell death, NADPH oxidases TNF, Amazing video of neutrophils targeting a cell March of the Neutrophils, Crawling Neutrophil Chasing a Bacterium Video, Chemotaxis in dictyostelium, Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2, GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils.

Cell Death, Apoptosis: Apoptosis Video Programmed cell clearance: molecular regulation of the elimination of apoptotic cell corpses and its role in the resolution of inflammation., Induction of caspase- and reactive oxygen species-independent phosphatidylserine externalization in primary human neutrophils: role in macrophage recognition and engulfment, Cell surface externalization of annexin A1 as a failsafe mechanism preventing inflammatory responses during secondary necrosis. Differences between necrosis and apoptosis, Macrophage Crawling Video

Plague-Yersinia pests: Deadly plague versus mild-mannered TLR4. Innate immune sensing of microbes by Nod proteins. Nod proteins link bacterial sensing and autophagy. cell wall of bacteria 1, 2, Crohn's disease susceptibility gene interactions, a NOD to the newcomer ATG16L1.Crohn's Video. Mitochondrion: an emerging platform critical for host antiviral signaling.

NK Cells video Natural killer cells and hepatitis C: action and reaction.In contrast to anti-tumor activity, YT cell and primary NK cell cytotoxicity for Cryptococcus neoformans bypasses LFA-1.A video of Immune synapse, Natural Killer Cells Require Selectins for Suppression of Subcutaneous Tumors, Analysis of Physiologic E-Selectin-Mediated Leukocyte Rolling on Microvascular Endothelium video Pregnancy immunogenetics: NK cell education in the womb? NK cell development, homeostasis and function: parallels with CD8+ T cells,

T-cells: Discussion of their discovery Video, T-cell receptor diversity, T-cell Development Video, Cytotoxic T-cell (also known as TC, CTL, T-Killer cell, cytolytic T cell, CD8+ T-cells or killer T cell): Perforin, Granzyme, Killer T-Cell Video, T Cell Granule Release Video, T-cell Killing Video.

TCR T cell antigen receptors and the immunoglobulin supergene family, T-Cell Receptor (TCR) Overview, T cell receptor signaling pathway, T-cell receptor pathways diagram VDJ Recombination Video, Second Signal Co-Stimulation of TCRs: CD28, CD-28 Pathway, CTLA-4, CD28-SuperMAB, CD28 and CTLA-4 coreceptor expression and signal transduction, Restless T Cells Sniff and Go, A single autoimmune T cell receptor recognizes more than a million different peptides.

Role of natural killer T cells in the mouse colitis-associated colon cancer model, T cell receptor signalling in gamma/deltad cell development: strength isn’t everything, Human gamma/delta T Cells: A Lymphoid Lineage Cell Capable of Professional Phagocytosis, Dendritic Cell Migration Video, White Blood Cell Chases Bacteria Video, NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

Major Histocompatibility Complex Video, MHC Class I Processing, The transition from the innate immune system to the acquired acquired immune system, Antigen Processing Video,

HLA class I molecules, MHC Class I Structure Video, HLA-A, HLA-B, HLA-C, HLA-G, Human leucocyte antigen-C in B chronic lymphocytic leukaemia

HLA class II molecules: Structure Video, HLA-DM, HLA-DR, HLA-DQ, HLA class II video, Excellent review video, Cross Presentation MHC class I endosomal and lysosomal trafficking coincides with exogenous antigen loading in dendritic cells, CD1, CD1 and lipid antigens: intracellular pathways for antigen presentation. Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice.

T Helper cells, Th1, Cytokines Proinflammatory: Interleukin I (IL-1), Tumor necrosis factor alpha (TNF-α) video, Type I Interferons in Host Defense, Interferon gamma (INF-γ), Il-6Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells REVIEW video, CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis

B-Cells B-cell Videoanother B-cell Video2, Gene Recombination Video, Viral double-stranded RNA triggers Ig class switching by activating upper respiratory mucosa B cells through an innate TLR3 pathway involving BAFF, Structure and function of immunoglobulins, Fc Receptors, Clinical consequences of defects in B-cell development, Somatic Hyper Mutation. Cannabinoid receptor 2 mediates retention of immature B cells in bone marrow sinusoids, Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone, TLR-mediated B cell activation results in ectopic CLIP expression that promotes B cell-dependent inflammation.,

Th2: IL-10, IL=13, Similarity and diversity in macrophage activation by nematodes, trematodes, and cestodes. Neurohormonal-cytokine interactions: implications for inflammation, common human diseases and well-being.,Neurohormonal-cytokine interactions: implications for inflammation, common human diseases and well-being, Glucocorticoids and the Th1/Th2 balance, Interleukin-10 promotes NK cell killing of autologous macrophages by stimulating expression of NKG2D ligands. CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis.

VDJ Recombination video,T-cell maturation video, T-cell signalling video, Second signal CD28 B7 Cannabinoid receptor type 1 and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling.

Resveratrol improves neuron protection and functional recovery in rat model of spinal cord injury

Th17: FoxP3+ CD4+ T cells in systemic autoimmune diseases: the delicate balance between true regulatory T cells and effector Th-17 cells,

Complement drives Th17 cell differentiation and triggers autoimmune arthritis, Regulatory role of resveratrol on Th17 in autoimmune disease

Th17 cells: a new fate for differentiating helper T cells

Antibody dependent Cell Mediate Cytotoxicity: Ca2+ signals during ADCC, Antibody dependent Cell Mediate Cytotoxicity: CD8 T-cell macrophage interaction Video Ca2+ signals during ADCC


IgA: IgA deficiency, The surprising discovery that TGF beta specifically induces the IgA class switch, Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL, Immunoglobulin responses at the mucosal interface, Probiotic bacteria and intestinal epithelial barrier function, Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors,

Coeliac disease: dissecting a complex inflammatory disorder.

The function and regulation of immunoglobulin D.IgD:


Cannabinoid receptor 2 (CB2) mediates immunoglobulin class switching from IgM to IgE in cultures of murine-purified B lymphocytes

IgG: Antibody technology: Video Wiki Definition, list of monoclonals hybridoma based monoclonals, phage display: pComb3, scFv (single chain variable fragment), Fab, Morphosys, technical manual, Beyond natural antibodies: the power of in vitro display technologies.

Vaccination: Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease, Vaccine's Safety: A Crime Against Humanity video, Contaminated Vaccines can create new Pandemics and Diseases video, Bill Gates says - Vaccine safety skeptics kill children! video, Proof of Vaccine Autism Link - Fox News video.

Cancer Immunology: Antibodies Target Inside Cancer cells?

Epigenetics: Epigenetic control of the immune escape mechanisms in malignant carcinomas.

Adaptive Transfer: Ex vivo gene transfer for improved adoptive immunotherapy of cancer, Inflammation and Cancer: Inflammation: gearing the journey to cancer.

Videos, Influenza antibody, Origins of H1N1, PowerPoint Slides, hyperinflammatory response to some strains: Targeted deletion of cannabinoid receptors CB1 and CB2 produced enhanced inflammatory responses to influenza A/PR/8/34 in the absence and presence of {Delta}9-tetrahydrocannabinol, Modulation Of Airway Responses To Influenza A/PR/8/34 By Delta-9-Tetrahydrocannabinol In C57BL/6 Mice.




Down regulating immune response to fetus Bi-Directional Calcium Signaling Between Adjacent Leukocytes and Trophoblast-Like Cells


Calcium dependent Fc receptor signaling A cell permeant peptide containing the cytoplasmic tail sequence of Fc receptor type IIA reduces calcium signaling and phagolysosome formation in neutrophils

LeukotrienesSelective localization of recognition complexes for leukotriene B4 and formyl-Met-Leu-Phe within lipid raft microdomains of human polymorphonuclear neutrophils.

TLR4 mediates human retinal pigment epithelial endotoxin binding and cytokine expression

Lipid Communication Lipid Mediators in Health and Disease: Enzymes and Receptors as Therapeutic Targets for the Regulation of Immunity and Inflammation.

Targeted deletion of cannabinoid receptors CB1 and CB2 produced enhanced inflammatory responses to influenza A/PR/8/34 in the absence and presence of {Delta}9-tetrahydrocannabinol.

Peanuts can contribute to anaphylactic shock by activating complement.

The role of the anaphylatoxins in health and disease.