Research Associates

BioFrontiers Research Associates

Ke (Jack) Jiang    

     Ke (Jack) Jiang, PhD

     Research Associate
PhD (Chemistry) 2009 Texas Christian University



 Research Interests 

- Gold/silver nanoparticles-polymer composite gels for photothermally enhanced laser treatments.

- Fluorescent gold/silver nanoclusters as stable and biocompatible probes for bio-imaging and bio-sensing applications.

- Three-dimensional gold/silver nanoparticle arrays for Surface Enhanced Raman Spectroscopy.

Recent publications

- K. Jiang, L. Ma, J. Wang, W. Chen, "Graphene oxide and reduced graphene oxide: synthesis, photoluminescence and biotechnology applications," Rev. Nanosci. Nanotechnol. (2013) In press.

- K. Jiang, G. R. Akkaraju, J. L. Coffer, " Silicon nanowire/polycaprolactone composites and their impact on stromal cell function," J. Mater. Res. 28, 185 (2013).

JHH3Janusz Hankiewicz, PhD

Senior Research Associate

PhD (Solid State NMR) 1988 A. Mickiewicz University, Poznan, Poland


CU New Inventor of the Year

Research Interests

Nuclear Magnetic Resonance Thermometry- Temperature is a fundamental parameter reflecting the biological status of the body and individual tissues. Clinical studies have indicated that localized temperature measurements could be a useful method for detection of a variety of health problems including certain cancers and inflammations. Precise determination of tissue temperature is also important in different medical interventional procedures such as hyperthermia treatment and thermal ablation.  Additionally temperature mapping is critical for monitoring temperature of tissue around medical metallic implants during standard magnetic resonance imaging and caused by fast switching magnetic gradients and radio-frequency (RF) pulses.

Magnetic Resonance Elastogrpahy- MRE is a new diagnostic method that uses phase contrast magnetic resonance imaging to detect organ tissue response to low energy mechanical waves for an in vivo, noninvasive and quantitative determination of tissue elasticity. Low-amplitude harmonic oscillations (of less than 10 microns) at acoustic frequencies (typically several hundred Hz) are introduced to the body by means of electromagnetic, piezoelectric or pneumatic driven actuators.  The propagation of the wave can be recorded using standard MRI protocols with the association of additional motion sensitizing gradients (MSG).  The spatial direction of the gradients can be changed to obtain a true three-dimensional vector of the tissue displacement.  The temporal and spatial elements of the wave field are then analyzed to provide a meaningful transformation of the wave data to form an image of the tissue stiffness.

The most important medical applications of this novel method of measurement of tissue stiffness currently include:

  1. Examination of brain development, injury and pathophysiology
  2. Liver fibrosis and inflammation
  3. Study of impaired contractility
  4. Breast cancer surveillance
  5. Assessments of skeletal muscle mechanical properties in training and physical therapies

Microprobes for nuclear magnetic resonance spectroscopy

NMR in local magnetic Field

Recent Publications

1.    Hankiewicz J.H., Yasar T.K., RoystonT.J. and Lewandowski E.D., In vivo Magnetic Resonance Elastography (MRE) in Mouse Heart at Ultra-High Magnetic Field Poster, Conference on Cardiovascular Research, Chicago, August 2011.

2.    Hankiewicz J.H., Banke H.N., Farjah M. and Lewandowski E.D. Early impairment of transmural principal strains in the left ventricle wall following short-term, high fat feeding of mice predisposed to cardiac steatosis. Circulation: Cardiovascular Imaging 3:710-717, 2010. PMID: 20837747.

3.    Hankiewicz J.H., Hausler Banke N. and Lewandowski E.D. Critical level of intramyocardial lipid impairs transmural principal strains in hearts of low overexpressing PPARa  mice due to high fat diet. American Heart Association Scientific Sessions, Orlando Fl, 2009 (Abstract).


1.    "Development of Contrast for Magnetic Resonance Imaging for Non-Invasive in vivo Temperature Measurement" from Bioscience Discovery Evaluation Program (with Robert Camley and Zbigniew Celinski)

     Guy Hagen   Guy Hagen

                                               Research Associate
                                               PhD (Chemistry) 2005 Colorado State University              

Research Interests

-Structured illumination microscopy (SIM)

-Single molecule localization microscopy (PALM/STORM)

-Bio-image informatics

-Live cell imaging

-Total internal reflection fluorescence microscopy (TIRF)

Recent Publications:

  1. Ovesný, M., Křížek, P., Švindrych, Z., and Hagen, G. M. (2014). High density 3D localization microscopy using sparse support recovery. Optics Express, 22, 31263-31276.
  2. Lukeš, T., Křížek, P., Švindrych, Z., Benda, J., Ovesný, M., Fliegel, K., Klima, M., and
    Hagen, G. M., (2014). 3D super-resolution structured illumination microscopy with maximum
    a posteriori probability image estimation. Optics Express, 22, 29805-29817.
  3. Lukeš, T., Hagen, G. M., Křížek, P., Švindrych, Z., Klima, M. (2014). Comparison of image reconstruction methods for structured illumination microscopy. Proc. SPIE 9129, 91293J.
  1. Ovesný, M., Křížek, P., Borkovec, J., Švindrych, Z., and Hagen, G. M. (2014). ThunderSTORM: a comprehensive ImageJ plugin for PALM and STORM data analysis and super-resolution imaging. Bioinformatics, 30, 2389-2390.
  2. Křížek, P., Raška, I., and Hagen, G. M., (2012). Flexible structured illumination microscope with a programmable illumination array. Optics Express, 20, 24585-24599.
  3. Křížek, P., Raška, I., and Hagen, G. M., (2011). Minimizing detection errors in single molecule localization microscopy. Optics Express 19, 3226-3235.


Former Research Associates

Kathrin Spendier, PhD      Research Associate (2012-2013)

Timothy Fal, PhD                  Research Associate (2013-2014)